How DataCore Analytics Keeps Data Confidential
12 May 2026
Variant analysis built for African genomes — where reference bias, population structure and under-representation in annotation databases all matter.
African populations carry more genetic diversity than the rest of the world combined, and are the most under-represented in the reference panels and annotation databases that variant pipelines depend on. A pipeline tuned on European cohorts will systematically miss and misclassify variants in African samples.
We build that into how we work: appropriate reference panels, population-specific allele frequency filters, and honest reporting of where annotation coverage is thin.
Each project uses the subset of these that your research question requires.
GATK best practices or DeepVariant for germline SNVs and indels, joint genotyping across cohorts, and structural variant and copy number calling where the data supports it.
Functional annotation with VEP, ANNOVAR or SnpEff against ClinVar, gnomAD, dbNSFP and African-specific frequency resources, with variants prioritised by consequence, frequency and inheritance model.
De novo, recessive and compound heterozygous filtering across trios and families, with phenotype-driven ranking using HPO terms and Exomiser.
Quality control, population stratification via principal components, imputation against appropriate reference panels, and association testing with PLINK, REGENIE or SAIGE — including mixed models for related samples.
Admixture and ancestry inference, runs of homozygosity, fixation index and selection scans for population and evolutionary studies.
Typical turnaround: 3–5 weeks for exome or genome cohorts; 2–4 weeks for GWAS from array data
Indicative price: From $99 per sample for exome calling and annotation at cohort scale
Reduced rates are available for students and researchers at African public institutions. Every project is quoted in writing before work begins.
Services are provided for research purposes only. They are not intended for clinical diagnosis, treatment decisions or individual health assessment. See how it works, data submission guidelines and what you receive.
Bioinformatics, biostatistics and data science support for research teams across Africa.
12 May 2026
28 April 2026