Pathogen Genomics & Genomic Surveillance

Genomic surveillance analysis with turnaround measured in days, built for public health laboratories that need results while they still matter.

Sequencing capacity for pathogen surveillance expanded sharply across Africa during the COVID-19 response. Analysis capacity did not follow at the same rate, and many national laboratories are now generating sequence faster than they can interpret it.

This is the work our consultants have done most: SARS-CoV-2 lineage assignment, Mycobacterium tuberculosis resistance profiling, Plasmodium falciparum drug resistance markers, and outbreak reconstruction for bacterial pathogens. We can work as a standing analysis partner to a surveillance programme, with agreed turnaround per batch.

Data We Accept

  • Raw FASTQ from Illumina or Oxford Nanopore amplicon or shotgun sequencing
  • ONT POD5 or FAST5 signal files for rebasecalling
  • Consensus genome FASTA files for downstream phylogenetics
  • Existing assemblies for comparative or outbreak analysis
  • Sample metadata with collection date and location

Questions We Answer

  • Which lineages are circulating in our surveillance catchment?
  • Are these cases part of one transmission chain?
  • What resistance mutations are present in these isolates?
  • Where did this outbreak strain come from, and when was it introduced?
  • Are our consensus genomes good enough to submit?

What We Do

Each project uses the subset of these that your research question requires.

01

Consensus Genome Assembly

Reference-based or de novo assembly with primer trimming, coverage assessment and quality flagging — including honest reporting of genomes too incomplete to submit.

02

Lineage and Clade Assignment

Pangolin and Nextclade for SARS-CoV-2, MLST and cgMLST for bacteria, and appropriate typing schemes for other pathogens, with submission-ready output for GISAID, ENA or Pathogenwatch.

03

Phylogenetics and Outbreak Reconstruction

Maximum likelihood and Bayesian phylogenies, time-calibrated trees, transmission cluster identification and phylogeographic reconstruction with IQ-TREE, BEAST and Nextstrain.

04

Antimicrobial and Drug Resistance

Resistance gene and mutation detection against CARD, ResFinder, TBProfiler and species-specific databases, reported as an interpretable resistance profile rather than a raw gene list.

05

Surveillance Dashboards and Reporting

Recurring batch analysis with standardised reports and, where wanted, a Nextstrain build your team can host and update.

What You Receive

  • Consensus FASTA files with per-genome quality flags
  • Lineage, clade and typing report in a submission-ready format
  • Annotated phylogenetic trees with metadata overlays
  • Mutation and resistance profile tables
  • Repository submission files for GISAID, ENA or NCBI
  • Batch summary report suitable for circulation to health authorities

Tools We Use

  • iVar, ARTIC, viralrecon
  • Dorado, medaka, Flye, Unicycler
  • Pangolin, Nextclade, Nextstrain
  • IQ-TREE, RAxML, BEAST2, TreeTime
  • snippy, Roary, Panaroo
  • TBProfiler, ResFinder, abricate, AMRFinderPlus

Typical turnaround: 1–2 weeks per batch; standing surveillance partners get agreed turnaround per run

Indicative price: From $19 per genome for consensus assembly and lineage assignment at batch scale

Reduced rates are available for students and researchers at African public institutions. Every project is quoted in writing before work begins.

Services are provided for research purposes only. They are not intended for clinical diagnosis, treatment decisions or individual health assessment. See how it works, data submission guidelines and what you receive.

Contact DataCore Analytics

Tell us about your data and we will scope it — free, within one working day.

+233 558 017 827